Degradation of purines: only ureidoglycollate lyase out of four allantoin-degrading enzymes is present in mammals.
نویسندگان
چکیده
It is generally accepted that all of the allantoin-degrading enzymes (allantoinase, allantoicase, ureidoglycollate lyase and urease), used in purine degradation, were lost during mammalian evolution. However, surprisingly, ureidoglycollate lyase has been found in a mammalian tissue. Ureidoglycollate lyase was purified to homogeneity and characterized from rat-liver mitochondria. The apparent Km (17 mM) of the rat enzyme for ureidoglycollate was much higher than that (0.33 mM) of fish-liver ureidoglycollate lyase. The rat-liver enzyme differed from the fish-liver enzyme in enzymic, physical and immunological properties.
منابع مشابه
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عنوان ژورنال:
- The Biochemical journal
دوره 312 ( Pt 1) شماره
صفحات -
تاریخ انتشار 1995